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Daily creatine monohydrate supplementation keeps those stores saturated so 5g every day with a meal is all it takes

doi: 10.1016/j.ecoenv.2021.112947 150 YuanATStillmanMJ

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These include deficiencies in protein, vitamin B-12, copper, iron, and of course stress

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Our data reveal that the conserved RGKT motif plays a dual role in the complex, by mediating direct contacts between SMAX1 D2 and MAX2, and by allosterically stabilising MAX2 LRR17 in its HTL7-binding position