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Recent Findings In obesity, there is an imbalance in gut microbiota composition and low-grade chronic inflammation, which alters satiety control mechanisms, leading to increased intestinal permeability, resistance to leptin and insulin, ghrelin dysfunction, and dysregulation of dopamine, serotonin and neuropeptides (inclusing increased orexigenic NPY, and AgRP)

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Jannel S, Caro Y, Bermudes M, Petit T

Lastly, its important to always purchase supplements from trusted brands that independently test their products for quality and purity using organizations like USP and NSF International