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For many patients, pausing medication is a short-term step that greatly improves safety and reduces the likelihood of complications

until at least 2032, when the first main patent for the drug, held by Novo Nordisk,expires

Compared with other oral hypoglycemic agents, the prevalence of PD when using DPP4 inhibitors and GLP-1RAs was shown to be 36-60% lower (76)

And on April 1, the Food and Drug Administration (FDA) approved Foundayo (orforglipron), a pill for adults with obesity or who are overweight and have a weight-related medical condition

Practically, if you are on a dose above 5mg, you may want to consider larger vial sizes

According to American Thyroid Association guidelines, treatment is typically initiated when TSH rises above 10 mIU/L or when TSH is between 4.5-10 mIU/L with symptoms or positive thyroid antibodies