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Surgery confers multiple downstream benefits: Lower rates of obesity-related comorbidities (like hypertension, hyperlipidemia, sleep apnea) compared to GLP-1 therapy at follow-up JAMA Network Reduced health care utilization: fewer inpatient stays, outpatient visits, and ED visits per patient per month post-surgery compared to GLP-1 therapy

Digestion and Gastrointestinal Effects GLP-1 medications intentionally slow digestion

Our 1000mg dose is double that studied threshold

Unlike whole-body Gclc KO mice, liver-specific Gclc L-KO mice did not have any difference in survival or body weight following Gclc deletion (Fig

Most GI effects are mild to moderate and often diminish over weeks to months as the body adapts to the medication

Youll store opened Lantus vials in the refrigerator or at room temperature for up to 28 days