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Binding of GIP to its receptor also stimulates glucose-dependent insulin secretion and produces a greater proportion of the incretin effect than GLP-1 (about 45% for GIP and 29% for GLP-1) [133]

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If side effects feel worse over time instead of better, it is important to speak with a provider

If this pattern holds for retatrutide, nasal delivery could offer a GI-tolerability advantage for individuals who respond well to the central appetite effects but struggle with peripheral GI symptoms