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Frequently Asked Questions How much vitamin B12 should I take daily

While it is uncertain whether these alterations also involve modified incretin responses, within the framework of obesity, MetS and the use of hydrochlorothiazide for treating hypertension associated with these conditions, these findings suggest an intriguing hypothesis: that overweight or overnutrition might amplify the metabolic effects of these diuretics by inhibiting NCC and/or other targets in -cells and in metabolically active tissues but independently of insulin secretion

doi: 10.1016/j.cmet.2020.11.016 36 YamadaTHabaraOKuboHNishimuraT

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Diabetologia 54, 965978

Treatment is typically started at 1ml/cc per injection once weekly