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Burt Solorzano CM, McCartney CR

In an in vivo study, administration of MOTS-c intraperitoneally to de-ovalized osteoporotic mice once daily for 12 weeks at a dose of 5 mg/kg, lead to an increased positive trend in several bone formation parameters, such as bone mineral density, bone volume/tissue volume, bone trabecule number, and bone trabecule thickness, indicating that the MOTS-c intervention effectively reduced bone loss

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IGF-1 LR3 activates the PI3K/Akt/mTOR signaling pathway, which drives protein synthesis in muscle tissue

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