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Using single neuron ex vivo electrophysiological recordings from genetically identified histaminergic (HDC) neurons, we demonstrated that approximately 40% of histaminergic neurons are excited by the non-selective MC3R/MC4R agonist melanotan II (MTII) or a selective MC4R agonist (THIQ) (147)

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Researchers comparing the two in a laboratory setting must account for the half-life differences

Stack rationale is built from individual-compound evidence and the mechanistic case for no receptor overlap

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Many physicians working in the peptide space believe the compound has meaningful healing potential based on the animal evidence and patient-reported outcomes