You conclude that 7.5 mg is "too much" and drop back to 5 mg
The inflammatory environment in HS involves elevated TNF-alpha, IL-17, and IL-23, cytokines that respond favorably to weight reduction
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This gradual escalation continues in 2.5 mg increments through 7.5 mg, 10 mg, 12.5 mg, and up to the maximum dose of 15 mg per week
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This guide covers: How each medication works (completely different mechanisms) Weight loss effectiveness: what the research shows Side effect profiles and tolerability Who each medication helps most (different eating patterns) Cardiovascular considerations Cost and insurance comparison Contraindications and safety concerns Practical aspects of taking each medication How to decide between them Key Takeaways Ozempic produces significantly greater weight loss (15% average) compared to Contrave (5-8% average) Different mechanisms: Contrave targets reward pathways and cravings
