Because vitamin B 12 in supplements is not bound to protein, and because intrinsic factor (IF) is still available, the absorption of supplemental vitamin B 12 is not reduced as it is in pernicious anemia
Taking a vitamin B complex is recommended because there is evidence that a combination of neurotropic B vitamins is more effective than taking a single vitamin B supplement, due to the synergies between the different vitamins.
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Drug Delivery and Translational Research, 9 (3), 625630
It also has the nutrients found in studies to treat male infertility
Generally, the benefits can last from several days to a few weeks, and regular maintenance injections may be recommended for sustained results