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Journal of Applied Physiology , 96(3), 1055-1062

Always consult a healthcare provider before combining these medications

Timing Optional Marker ESR Why it matters Adds another broad inflammation marker when symptoms, autoimmune history, or persistent swelling are part of the picture

And here is the important part: if you miss two or more consecutive doses, you may need to restart the full titration schedule from 0.25 mg to avoid severe gastrointestinal side effects

A summary of evidence