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In preclinical models, inhibiting this receptor has been shown to mimic some of the physiological effects of endurance exercise

With respect to definition of controls, most studies recruited healthy children with no information about family history of autism spectrum disorders, although, four studies did ensure that controls did not have either a family history or sibling with autism [70, 75, 77, 87] and one screened for autism traits [59]

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Minimizing and managing side effects Proactive strategies reduce the likelihood of side effects and help manage any that occur