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3.8.4 Ferroptosis Ferroptosis refers to a specific PCD paradigm resulting from unrestrained lipid peroxidation (128)

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In parallel, iron-handling disturbances (such as labile iron accumulation and ferritinophagy-mediated iron release) initiate a pre-ferroptotic state, lowering the threshold for ferroptotic execution upon inflammatory or mechanical insults (13,14)