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Combination therapies, which include both oral medications and injectables, offer a more holistic approach to diabetes management

Deficiency typically presents as unexplained fatigue, numbness or tingling, and macrocytic anemia

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doi: 10.1016/j.yebeh.2012.06.016 3

Figure 2 5.1 A new perspective on the pathogenesis of diabetes: beyond insulin deficiency While diabetes has traditionally been characterized by insulin deficiency or resistance, accumulating evidence suggests that hyperglucagonemia and impaired glucagon signaling are equally critical contributors to its pathogenesis