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PMID: 116 SabagAPattenRKMoreno-AssoAColomboGEDafauce BouzoXMoranLJet al

A comprehensive proteomic study of platelets in patients with T2DM and mild cognitive impairment (T2DM-MCI) versus those without (T2DM-nMCI) revealed that differentially expressed proteins are primarily involved in amyloidosis, mitochondrial autophagy, and insulin signaling pathways (Yu et al., 2021)

By integrating these findings, it becomes clear that lipedema is sustained by a network of interrelated mechanisms, chronic inflammation, fibrosis, mitochondrial dysfunction, and hormonal imbalance, that reinforce one another and explain the diseases resistance to conventional interventions

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