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Elevated stiffness promotes breast tumor progression by increasing angiogenesis and vascular permeability [76] as well as breast cancer cell proliferation [77], stemness [78], and metastasis [70]

doi: 10.3389/fphar.2017.00904

In contrast, the following features indicate pain sources outside the bladder and a higher risk of failure: Large capacity under anesthesia Absence of Hunner lesions, Lack of relief with local anesthetic bladder instillations, Pelvic muscle tightness/tenderness, Genital hyperesthesia, Pain beyond the pelvis, such as the presence of widespread pain, and, most important, Polysymptomatic or polysyndromic presentation

Out of many examples of his speaking in the seminars, one notable example is the Olympic training center in New York, where he was invited to speak about sports fitness

In this context, Li et al