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In the context of food-seeking behaviors, GLP-1 administration has been shown to decrease mesolimbic dopaminergic signaling [152]

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Glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter 2 inhibitors and risk of nonalcoholic fatty liver disease among patients with type 2 diabetes

PLoS Genet 1: e36

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Observed side effects in research environments are generally mild and temporary, most commonly including: Temporary fatigue-related observations Mild fluid-retention variability Increased hunger- or appetite-related observations Mild headache-related observations Minor administration-site irritation such as redness or temporary administration-site sensitivity observations Proper reconstitution, sterile handling practices, proper administration techniques, and regular administration-site rotation are important for minimizing local irritation and maintaining peptide stability and consistency during research use