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Yes, some patients experience deficiency symptoms despite borderline-normal serum B12 levels

Quality of life improvements Multiple quality-of-life domains showed significant improvement

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But if your body doesnt have the raw materials , regeneration stalls

Excess B12 from oral supplements is poorly absorbed at high doses (the body absorbs roughly 1 to 2% of a 1,000 mcg oral dose) and the remainder is excreted in urine