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Novo Nordisk - Regulatory Approval (December 2025): FDA approved the first oral GLP-1 for weight loss-Novo Nordisk's once-daily semaglutide pill-which launched in January 2026 [3]

Substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimers disease and dementia), cardiometabolic disorders, chronic kidney disease, COPD, pneumonia, liver failure, inflammatory bowel disease, liver cancer) all significantly declined

A personal or family history of medullary thyroid carcinoma rules you out

J Biol Chem 287:3573335746 Zhu S, Huang M, Feng G et al (2018) Gelatin versus its two major degradation products, prolyl-hydroxyproline and glycine, as supportive therapy in experimental colitis in mice

Being monitored by a clinician throughout treatment should be a priority