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doi: 10.1016/j.ahj.2023.09.007 85 NauckMADAlessioDA

In 2024, tirzepatide also gained authorization for managing moderate-to-severe obstructive sleep apnea (OSA) in obese adults (Malhotra et al., 2024)

10.1101/lm.037267.114 44 GejlM.GjeddeA.EgefjordL.MollerA.HansenS

Lower starting doses (1-4 mg weekly) are recommended to minimize gastrointestinal side effects , with titration over 4-8 weeks

Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]