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These factors include systemic inflammation (Zobel et al., 2021), hyperglycaemia (Mapanga and Essop, 2016), increased endothelial production of reactive oxygen species (ROS) (Li et al., 2017

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DDX3, a DEAD box RNA helicase with tumor growthsuppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor