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Your appetite may begin declining toward the end of week one, but the appetite-suppressing effects intensify considerably in weeks two through four

10.1136/ard-2023-223845 [DOI] [PMC free article] [PubMed] [Google Scholar] 50.Samajdar SS, Bhaduri G, Ghoshal PK, Mukherjee S, Pal J, Chatterjee N, Joshi SR (2024) Dual effects of dulaglutide on glycemic control and knee osteoarthritis pain in elderly patients with type 2 diabetes

doi: 10.1111/jvim.12152

For researchers using tirzepatide sourced from vendors with known weight accuracy issues, an additional safety consideration arises

[15] [17] If you are already taking urate-lowering therapy such as allopurinol or febuxostat, you should continue this medication as prescribed unless advised otherwise by your doctor

Medication cost is separate and varies by type