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Stop using Saxenda and get medical help right away if you have any symptoms of a serious allergic reaction including swelling of your face, lips, tongue, or throat, fainting or feeling dizzy, very rapid heartbeat, problems breathing or swallowing, or severe rash or itching depression or thoughts of suicide

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A weekly formulation of exenatide called Bydureon was approved in 2012

The FDA required manufacturers to add a warning about this risk to the label in 2005 and said it would continue to monitor reports of suicide or suicide attempts linked to isotretinoin

Nature 359(6398):843845 Davis S et al (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

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