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and (ii) melatonin avoids mPTP opening and mitophagy-mediated cell death by suppressing mitochondrial fission following ischemia reperfusion injury that in turn restored bound VDAC1-HK2 (ref

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Over time, this cellular protection can translate into improved physical stamina, a higher threshold for exertion, and a reduction in the severity of post-exertional crashes

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The nasal route facilitates non-invasive administration, avoiding the need for injections or complex delivery systems, which may simplify protocol designs during experimental procedures