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[5] [6] In women, obesity is linked to: Anovulation and irregular menstrual cycles : Excess adipose tissue produces oestrogen and inflammatory mediators that disrupt the hypothalamic-pituitary-ovarian axis, leading to irregular or absent ovulation

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Nausea affects 3843% of patients during escalation but drops to 812% by month 6

Obes Rev 2017;18:8698 80