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Biodistribution study The biodistribution of NP4 in orthotopic osteosarcoma mouse model was investigated using in vivo imaging system (IVIS)

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As H 2 O 2 and superoxide (O 2 ) ions have been reported to have an inhibitory effect on SOD and catalase activities, respectively, the authors have suggested that riboflavin deficiency may lead to an overproduction of reactive oxygen species (obviously through a mechanism independent of the glutathione redox cycle) beyond the scavenging ability of SOD and catalase

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