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Slow digestion can cause nausea and GI distress, suppress appetite These medications make it hard to eat or absorb enough fuel for training When fuel drops too low

It is important to note that use of medications such as beta blockers is contraindicated in these patients because they may result in syncope and increase the risk of death

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Very little semaglutide survives the stomach and reaches the bloodstream when its swallowed, so a tablet has to start with a much higher dose to have the same effect, and the highest dose of Rybelsus is 14 mg