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This was consistently visualized with different endothelial cell antigens, FVIII (involved in platelet adhesion and aggregation, present on endothelial cells of mature blood vessels) and CD34 (involved in leukocyte adhesion and endothelial cell migration during angiogenesis, present on capillary endothelial cells), as well as with VEGF presentation (main factor in angiogenesis, expressed on endothelial cells, mitogen for vascular endothelial cells)

T4 (the parent of TB-500) is a well-documented promoter of endothelial cell migration and new-vessel formation