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It can modulate the activity of enzymes involved in the production of inflammatory mediators, such as lipoxygenase and cyclooxygenase, thus reducing oxidative stress and inflammation [215]

These include: Older adults on PPIs or H2 receptor antagonists Diabetic patients on metformin for a long time People with gut disorders that affect nutrient absorption Its important to check these individuals B12 levels to avoid deficiency

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Researchers can study GH-axis signaling pathways, receptor binding kinetics, and downstream cellular responses without the confounding hormonal noise introduced by less selective compounds

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According to reports, curcumin is a P450 inhibitor that inhibits CYP2C9, CYP1A2, CYP2D6, CYP2B6 and CYP3A4, with particularly low IC50 values for CYP2C9 (Sasaki et al., 2017)