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Gomez-Manzo et al

Secondly, HOCl/OH can activate enzyme complexes involved in DNA repair (such as APE1, PARP, DNA ligase) to assemble at DNA damage sites, promoting chromatin decondensation and further enhancing NETs/NETosis [247]

10.1016/S0015-0282(16)58456-8 79

149,150,151 Tau protein hypothesis As a major component of NFTs, tau protein exhibits a spatial and temporal distribution that strongly correlates with clinical symptoms, making it a highly specific pathological biomarker in AD patients

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