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Treatment of mice with oral melatonin (50 or 100 mg/kg) 4 or 8 hours before acetaminophen overdose suppressed the increase in serum ALT and AST activities in a dose- and a time-dependent manner, but had no effect on liver glutathione levels

But "gentle" does not mean "zero side effects," and anyone telling you otherwise is skipping pages in the research

Med 197 , 315322 (2003)

they can communicate information, sense danger when the cell energy levels drop, and are even involved in sending the final "death" message (apoptosis) when a cell is damaged beyond repair and needs to die

Results vary by patient

One key player in this response is posited to be MST1, a protein that increases its activity in the presence of oxidative stress