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These include the incorporation of the vitamins to the liposomes (Marsanasco et al., 2011), poly(lactic-co-glycolic) acid (PLGA) nanoparticles (Gambaro et al., 2022), nanostructured lipid carriers (Saez et al., 1984), chitosan carriers (Sherif et al., 2024), nanocapsules (Khayata et al., 2012), cyclodextrin complexes (Khan et al., 2023), and peptides and antibody conjugates (Jung et al., 2018)

The only shared thread is that both influence metabolic health, but through mechanisms so divergent that comparing them for weight loss efficacy is like comparing a multivitamin to insulin

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73 This may be because, like arginine, metformin is very high in nitrogen