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Its medicinal-chemistry program, described in detail by Kruse and colleagues, introduced several deliberate substitutions into the amylin backbone: residues borrowed from rat amylin (which does not readily form fibrils) to blunt the aggregation tendency, an engineered salt bridge to stabilize the central helix, and a C 20 fatty-diacid moiety attached through a linker to promote reversible binding to serum albumin
[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Caballero-Garcia A., Pascual-Fernandez J., Noriega-Gonzalez D.C., Bello H.J., Pons-Biescas A., Roche E., Cordova-Martinez A
Mori Y, Matsui T, Hirano T, Yamagishi SI
GLP-1 receptor agonists are not contraindicated with levothyroxine, but they may delay gastric emptying which could theoretically affect levothyroxine absorption