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Since 1978, when ELISA was first described [2], it became the gold standard antigen-antibody detection assay in basic research of which some assays were further optimized for diagnostic purposes and became commercially available

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Together, these results indicate that the abundance of mitochondrial CI is regulated by the circadian clock independently of direct transcriptional control

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But if you're relying on it every day to suppress your hunger because you're not eating enough real food, that's a problem