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Besides, the treatment improved the expressions of MMP-2 and MMP-9, TIMP-1 and TIMP-2 (tissue inhibitor of metalloproteinase) suggesting neuroprotection [50]

The link between the apoptosis and autophagy pathways can be attributed to the fact that autophagy decreases the levels of proapoptotic proteins in cells, increasing the threshold of stress required for the pressure threshold required for apoptosis to induce cell death

Pulse wave velocity (PWV) was measured to reflect vascular elasticity, with higher PWV indicating greater arterial stiffness

Study on the mechanism of glucocorticoid receptor mitochondrial translocation and glucocorticoid-induced apoptosis in macrophages

Blasko et al

Timing: Dosing is most often administered in the evening, shortly before bedtime, to align with its hypothesized promotion of SWS and natural circadian rhythms