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As a sealed powder stored cold and dry, most last for several years

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Persistent or worsening nausea beyond this timeframe should prompt reassessment for drug interactions, alternative diagnoses (e.g., gastroparesis), or consideration of anti-nausea medications

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Key finding: Retatrutide reduced activation in nucleus accumbens and lateral orbitofrontal cortex (p=0.014) and decreased self-reported hunger by 6.2 1.1 points vs 0.3 1.3 placebo

Meanwhile, social media increased interest in semaglutide among people who wouldnt qualify for the drug for FDA-approved reasons