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This rapid clearance may help prevent the toxic accumulation of mediators in the bloodstream, significantly reducing the severity and duration of systemic MCAS flares, such as flushing, gastrointestinal distress, and neurological inflammation

2.12 Cell transfection MCECs or MPMs were seeded in 6-well plates and transfected with siSTAT3 or the corresponding negative controls using Lipofectamine 2000 reagent