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In the PD Drosophila model, overexpression of Nrf2 and knockdown of Keap1 alleviate the decline in locomotor ability (170)

In humans, kidney removes 68 U of insulin per day by two major routes (Figure 2), that apparently have distinct preferential physiological goals: post-glomerular secretion (insulin signaling) and glomerular filtration (nutrient conservation and homeostasis) (Ritz et al., 2013)

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