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Key takeaways Zepbound is an FDA-approved brand-name prescription weight-loss drug

A Canadian company cleared a major regulatory hurdle, Novo Nordisk dramatically cut US Wegovy pricing, and the pan-Canadian Pharmaceutical Alliance laid the groundwork for generic pricing

Gene expression studies reveal the scope of GHK-Cu activity

Patients should also tell surgical and anesthesia teams about GLP-1 or tirzepatide treatment before procedures involving general anesthesia or deep sedation because current labeling includes warnings related to delayed gastric emptying and pulmonary aspiration

Adding unproven agents to an established GLP-1 therapy may introduce risk without proportional benefit

Clinical research studies must take place to confirm these results and create specific treatments through joint injections