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44 Subsequently, there have been postmarketing reports of severe cases of joint pain in patients receiving DPP-4 inhibitor therapy

That proposal is not yet finalized

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Furthermore, emerging studies provide evidence that SGLT2-i might have an interfering effect on aldosterone/renin ratio (ARR) in patients with T2DM, due to their diuretic and sympathoinhibition effects

References: Bravo L, Martnez-Lpez S, Sierra-Cinos JL, Mateos R, Sarri B