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Lipoic acid prevents high-fat diet-induced hepatic steatosis in Goto Kakizaki rats by reducing oxidative stress through Nrf2 activation
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Intensive Support Protocol For individuals with significant oxidative stress burdens, those recovering from illness or toxic exposures, or those pursuing more aggressive aesthetic goals, intensive protocols may involve 1000-2000mg administered 2-3 times weekly for defined periods (typically 8-12 weeks)
Age-related increases in oxidative stress have been associated with chronic inflammation, cardiovascular and neurodegenerative disease, osteoarthritis and type 2 diabetes in humans (Reference Cannizzo, Clement and Sahu4Reference Rains and Jain6) and companion animals, namely cats (Reference Brown7,Reference Vite and Head8) and dogs (Reference Brown7Reference Pizzirani10)
Endocrinology 156 , 43884397, (2015)