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33 recently reported that adipocyte Gcgr expression did not affect fasting-induced lipolysis in lean mice and the lack of effect of glucagon in lipolysis ex vivo in WAT explants from wild-type or adipocyte-specific GCGR-deficient mice

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This correlates with the significant disruption of the capillary network observed in the substantia nigra [232]

Most published work is in rodent models

A pro-oxidative shift caused by GSH depletion triggers glutathionylation of CASP8 at residues Cys360 and Cys409 81