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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice

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"It's important not to eliminate food groups," Gonsahn-Bollie says

[1] [2] This is characteristic of the incretin class as a whole and appears related to the pace of dose escalation

This approach allows patients to take control of their health and improve their quality of life while managing the symptoms of colitis