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Effects of a sodium-glucose cotransporter 2 inhibitor in nonalcoholic fatty liver disease complicated by diabetes mellitus: Preliminary prospective study based on serial liver biopsies

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Most other weight-loss medicines work on only one or two of those

In the kidney SGLT1 is responsible for approximately 10% of the transport of luminal glucose and thus inhibiting SGLT1 may facilitate SGLT2 induced loss of glucose in the urine (237,239)

Mechanistically, NAMPT can also regulate stemness in a paracrine manner through the senescence-associated secretory phenotype

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