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Any peptide can theoretically provoke an immune response

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doi: 10.1074/jbc.RA117.001163 77 RupertJENarasimhanAJengelleyDHAJiangYLiuJAuEet al

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A 2022 systematic review and meta-analysis published in JAMA Internal Medicine found that GLP-1 receptor agonist use was associated with increased risk of biliary disease, with an overall relative risk of approximately 1.37