However, it provides an option for individuals trying to improve their metabolic health without needing big treatments
Moreover, metformin produces robust induction of islet gene expression and incretin responsiveness
NHS access for weight management is more restricted
Patients who did not take phentermine after discontinuing GLP-1 (N=34,668) Patients who started phentermine after discontinuing GLP-1 (N=7,773) Adapted with permission from Bartlet et al
Weeks 1-4: 1mg weekly (4mg total, small portion of first vial) Weeks 5-8: 2mg weekly (8mg total) Weeks 9-12: 4mg weekly (16mg total, finish first vial and start second) Weeks 13-16: 6mg weekly (24mg total, continue through second vial) Weeks 17-20: 8mg weekly (32mg total) Weeks 21-24: 8mg weekly maintenance (32mg total) Total peptide required: 116mg over 24 weeks Vials needed: 6 x 20mg vials with some remaining This protocol reaches 8mg maintenance by week 17 and holds there through week 24
Tirzepatide is a once-weekly dual GIP and GLP-1 injection