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We surmised that pU L 31 may capture DDX3X at the nuclear membranes and evaluated if the absence of pU L 31 would alter the intracellular localisation of DDX3X

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Enrichment analysis using Metascape also identified 10 DEPs involved in mitochondrial organization (i.e., 4 and 6 were up- and downregulated, respectively, after HC treatment) (Figure 5D) with a downregulation, for example, of AKT1, TOMM20 (translocase of the outer mitochondrial membrane 20), and RRM2B (Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B), and an upregulation of MTFR1 (mitochondrial fission regulator 1) and MIEF1 (mitochondrial elongation factor 1)

Department of Pharmacy, University of Karachi, Pakistan

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In clinical studies, patients report feeling a reduction in both chronic pain and chronic fatigue within 24-48 hours following IV treatment