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These changes often occur within 48 weeks, suggesting that anti-inflammatory effects begin quickly

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( i ) Pie chart representing the percentage of semaglutide-responders or Fsk only responders in each condition

Dopamine is the predominant catecholamine in mammalian brain and is involved in neurological functions such as locomotion, cognition, emotion and reward [15, 16]

Statistics and reproducibility For animal studies, sample sizes were calculated based on a power analysis assuming that a body weight difference of 5 g between the treatment groups can be captured with a power of 75% when using a two-sided, two-tailed statistical test under the assumption of a s.d

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