Lipid-nucleic acid nanoparticles of novel ionizable lipids for systemic BMP-9 gene delivery to bone-marrow mesenchymal stem cells for osteoinduction
Current Pharmaceutical Design , 2020 Cytoprotective Effects on the Gut: Orally administered BPC-157 has shown promise in protecting the mucosal lining of the stomach and intestines , though oral bioavailability is debated
Atluri H, Mullin J, Takahashi K, Loghavi S, Maiti A, Sasaki K, Daver N, Valero YA, Pemmaraju N, Borthakur G, Hammond DE, Chien KS, Ferrajoli A, Short NJ, Abbas HA, Jabbour E, Andreeff M , Ravandi F, Tidwell RSS, Wang X, Konopleva MY, Garcia-Manero G, Kantarjian HM, DiNardo CD
J Nutr Sci Vitaminol.(Tokyo) 2001;47(6):378-384
By enhancing glutathione levels, one could potentially mitigate oxidative stress, but there is a nuanced balance
Animal data suggests this is sufficient for significant mucosal healing in models of inflammatory bowel disease and NSAID-induced injury