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Ring & Thomas, 1989

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Overall, these data support a model whereby hemeHPX could potentially interact with a plasma membrane HSPG, possibly by binding ligands and then presenting them, as suggested for LRP1, for endocytosis ( 4 Logical outcomes and future developments Recycling of HPX was calculated to account for the clearance of a heme load by plasma HPX in humans ( in vivo in rats (Smith and Morgan, 1978), in HepG2 cells (Smith and Hunt, 1990), and, as mentioned, in HL-60 cells

Researchers identified a hit, a drug that was developed nearly a decade ago

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All patients were either obese or overweight and had a history of heart disease